Storing Tirzepatide: Best Practices
❄️ Lyophilized Peptide Storage
Store lyophilized teduglutide vials at 2°C to 8°C (36°F–46°F) in the original carton to protect from light. Stable for up to 24 months under recommended conditions. Do not use beyond the expiration date printed on the vial.
💧 Reconstitution
Reconstitute each vial with 0.5 mL of the provided diluent (sterile water for injection). Gently swirl the vial for approximately 15 seconds — do not shake. Allow to stand for up to 2 minutes if undissolved powder remains, then gently swirl again. The reconstituted solution should appear clear and colorless.
⏰ After Reconstitution
Use within 3 hours of reconstitution. Keep at room temperature (20–25°C / 68–77°F) until administration. Do not refrigerate or freeze the reconstituted solution. Discard any unused portion after 3 hours.
❄️ Freezing
Do NOT freeze either the lyophilized vials or the reconstituted solution. If a vial has been frozen, it must be discarded.
🧴 Handling Precautions
Inspect the reconstituted solution visually prior to use. Do not use if the solution appears cloudy, discolored, or contains particulate matter. Each vial is accompanied by a Certificate of Analysis (COA) detailing purity verification via RP-HPLC and Mass Spectrometry (MS). This product is for research use only (RUO).
References
- Drucker DJ, et al. (1996). Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV. Nat Biotechnol, 15(7):673–677.
- Drucker DJ, Yusta B. (2014). Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2. Annu Rev Physiol, 76:561–583.
- FDA. (2012). NDA 203441 Approval Letter — Gattex (teduglutide) for injection. U.S. Food and Drug Administration.
- Drucker DJ, et al. (1996). Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci USA, 93(15):7911–7916.
- Jeppesen PB, et al. (2012). Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure. Gastroenterology, 143(6):1473–1481.
- Leen JLS, et al. (2011). Mechanism of action of glucagon-like peptide 2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts. Endocrinology, 152(2):436–446.
- Jeppesen PB, et al. (2005). Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients. Gut, 54(9):1224–1231.
- Gattex (teduglutide) Prescribing Information. (2019). Takeda Pharmaceuticals USA, Inc.
- Schwartz LK, et al. (2016). Long-term teduglutide for the treatment of patients with intestinal failure associated with short bowel syndrome. Clin Transl Gastroenterol, 7(2):e142.
- Jeppesen PB, et al. (2018). Factors associated with response to teduglutide in patients with short-bowel syndrome and intestinal failure. Gastroenterology, 154(4):874–885.
- Kocoshis SA, et al. (2020). Safety and efficacy of teduglutide in pediatric patients with short bowel syndrome—intestinal failure. J Pediatr Gastroenterol Nutr, 70(4):521–528.
- Hukkinen M, et al. (2019). Parenteral nutrition-associated cholestasis and its association with teduglutide treatment in neonatal short bowel syndrome. J Pediatr Surg, 54(11):2281–2287.
- Drucker DJ, et al. (1999). Glucagon-like peptide 2 reduces intestinal permeability. Am J Physiol, 276(6):G1420–G1426.
Related Research Questions
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This content is provided for educational and informational purposes only. Products are furnished for in-vitro studies only and are not medicines, drugs, or supplements. Not approved by the FDA to prevent, treat, or cure any condition.